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New Study Indicates That Obesity Is Linked To Reduction Of Brain Matter

In the United States, more than 2 in 3 adults are considered overweight or obese, more than 1 in 3 adults are considered obese, and more than 1 in 20 adults are considered extremely obese. This equates to approximately 68.8% of the entire U.S. population

It’s common knowledge that obesity increases the risk of health issues like heart disease, high blood pressure, type 2 diabetes, osteoarthritis, and a whole host of other problems.

Now new research suggests obesity may affect brain tissue as well.

Results from a study published in the journal Neurobiology of Aging found overweight people had a significant amount of reduction in the white matter of their brain, as compared to non-overweight people. 

Researchers hypothesized that obesity would affect the onset and progression of brain aging. Study results supported this, as the study authors found that the amount of reduction in white matter in an overweight person’s brain was similar to the amount of reduction in white matter in the brain of a non-overweight person 10 years older.

This cross sectional study gathered data from 473 participants between the ages of 20 and 87. It specifically looked at the effect of obesity on brain structure across the adult life span. Splitting the participants into two categories - lean and overweight, where the marker of “overweight” was anyone with a BMI 25 or over - researchers found the difference in white matter doesn’t start happening until middle age. This suggests our brains may be vulnerable during this time.

Dr. Lisa Ronan from the Department of Psychiatry at the University of Cambridge, and first author on this study, said:

“As our brains age, they naturally shrink in size, but it isn’t clear why people who are overweight have a greater reduction in the amount of white matter...We can only speculate on whether obesity might in some way cause these changes or whether obesity is a consequence of brain changes.”

White matter, also known as substantia alba, is the tissue that connects grey areas of the brain and allows information to be communicated between grey matter and other areas of the body. It also controls functions like temperature, blood pressure, and heart rate.

Brain shrinkage is linked to a higher risk of cognitive decline and dementia. However, this study found no difference in cognitive functioning, measured by an IQ test, between lean and overweight participants.

Professor Sadaf Farooqi from the Wellcome Trust-Medical Research Council Institute of Metabolic Science at Cambridge, and the report’s co-author, said:

"We don't yet know the implications of these changes in brain structure...Clearly, this must be a starting point for us to explore in more depth the effects of weight, diet and exercise on the brain and memory."

Aptly named, Enclothed Cognition is the official Medelita blog for medical professionals interested in topics relevant to a discerning and inquisitive audience. Medelita was founded by a licensed clinician who felt strongly about the connection between focus, poise and appearance.